Interactive effects of in vitro binge-like alcohol and ATP on umbilical endothelial nitric oxide synthase post-translational modifications and redox modulation
K Subramanian, VD Naik, K Sathishkumar… - Reproductive …, 2014 - Elsevier
Alcohol dysregulates the regulation of reproductive vascular adaptations. We herein
investigated chronic in vitro binge-like alcohol effects on umbilical endothelial nitric oxide
synthase (eNOS) multi-site phosphorylation and related redox switches under basal
(unstimulated) and stimulated (with ATP) states. Alcohol decreased endothelial excitatory
Pser1177 eNOS (P< 0.001), whereas excitatory Pser635 eNOS exhibited a main effect of
alcohol (↓ P= 0.016) and ATP (↑ P< 0.001). Alcohol decreased Pthr495 eNOS (P= 0.004) …
investigated chronic in vitro binge-like alcohol effects on umbilical endothelial nitric oxide
synthase (eNOS) multi-site phosphorylation and related redox switches under basal
(unstimulated) and stimulated (with ATP) states. Alcohol decreased endothelial excitatory
Pser1177 eNOS (P< 0.001), whereas excitatory Pser635 eNOS exhibited a main effect of
alcohol (↓ P= 0.016) and ATP (↑ P< 0.001). Alcohol decreased Pthr495 eNOS (P= 0.004) …
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