Interleukin 1-beta is linked to chronic low-grade inflammation and cardiovascular risk factors in overweight adolescents
GA Amaral, JD Alves… - … Metabolic & Immune …, 2020 - ingentaconnect.com
Endocrine, Metabolic & Immune Disorders-Drug Targets (Formerly …, 2020•ingentaconnect.com
Aim: We hypothesized that IL-1β concentrations are augmented in overweight adolescents,
who do not display metabolic syndrome. Additionally, we aimed to correlate the IL-1β
concentrations with several established risk factors for CVD. Methods: Overweight or control
subjects, aging from 14-18 years, were classified according to their adjusted body mass
index and evaluated for biochemical and anthropometric parameters. The proinflammatory
cytokine IL-1β was assessed in the serum. Results: Increased body fat percentage, waist …
who do not display metabolic syndrome. Additionally, we aimed to correlate the IL-1β
concentrations with several established risk factors for CVD. Methods: Overweight or control
subjects, aging from 14-18 years, were classified according to their adjusted body mass
index and evaluated for biochemical and anthropometric parameters. The proinflammatory
cytokine IL-1β was assessed in the serum. Results: Increased body fat percentage, waist …
Aim
We hypothesized that IL-1β concentrations are augmented in overweight adolescents, who do not display metabolic syndrome. Additionally, we aimed to correlate the IL-1β concentrations with several established risk factors for CVD.
Methods
Overweight or control subjects, aging from 14-18 years, were classified according to their adjusted body mass index and evaluated for biochemical and anthropometric parameters. The proinflammatory cytokine IL-1β was assessed in the serum.
Results
Increased body fat percentage, waist circumference, triglycerides, total cholesterol, Very Low-Density Lipoprotein (VLDL) cholesterol, Low-Density Lipoprotein (LDL) cholesterol, Castelli I index, IL-1β, and IL-8 levels, were observed in overweight adolescents. No differences were observed in systolic blood pressure, diastolic blood pressure, glucose or High-Density Lipoprotein (HDL) cholesterol. Positive correlations between IL-1β with anthropometric and or biochemical parameters were found.
Conclusion
In conclusion, increased IL-1β levels correlate to dyslipidemic factors and may further support low-grade inflammation. IL-1β may further predict the early onset of cardiovascular disease in this population, taking into consideration its important regulatory role.
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