过去一年中添加的文章,按日期排序

MSCs derived membrane coating nanoparticles targeted delivery itaconic acid to regulate M1 macrophage pyroptosis for osteoarthritis therapy

Y Dong, J Wan, H Xiao, J Wang, X Yu, Y Liu, S Lei… - Applied Materials …, 2024 - Elsevier
5 天前 - Intra-articular injection of nanoparticles protected joint cartilage against OA
development and reduced inflammatory response in the OA rat model. All in all, as a potential …

Advancements in pH-Responsive nanoparticles for osteoarthritis treatment: Opportunities and challenges

S Liao, S Jia, Y Yue, H Zeng, J Lin… - Frontiers in Bioengineering …, 2024 - frontiersin.org
37 天前 - … in the joint cavity through intra-articular injection to enhance therapeutic effects. As
… more accurate and efficient treatment of OA with pH-responsive targeted nanomaterials, and …

IntraArticular Injection of Nanomaterials for the Treatment of Osteoarthritis: From Lubrication Function Restoration to Cell and Gene Therapy

Y Yang, H Zhang - Advanced Functional Materials, 2024 - Wiley Online Library
72 天前 - Intra-articular injectable nanomaterials achieve targeting function. a) The optimal
net positive charge of avidin enables its rapid and high intracartilage uptake and long-term …

Uptake of various lipid nanoparticle formulations in canine osteoarthritic joint tissues for mRNA delivery

L Utomo, A Varela-Moreira, I Gill… - Osteoarthritis and …, 2024 - oarsijournal.com
103 天前 - Intra-articular injections of drugs such as corticosteroids or NSAIDs are often insufficient
… the possibility to target non-druggable targets and processes. Lipid nanoparticles (LNPs…

Dual-targeted lipid nanoparticles system for synergistic anti-inflammation and cartilage repair in the treatment of temporomandibular joint osteoarthritis

K Yang, Y Zhao, C Wang, Y Yu, X Zhang, J Liu… - Chemical Engineering …, 2024 - Elsevier
181 天前 - … In this study, we developed the dual-targeted LNPs for the intra-articular delivery
of miR-330-3p and KGN to suppress inflammation of macrophages and promote pro-chondral …

Intra-articular injection of stigmasterol-loaded nanoparticles reduce pain and inhibit the inflammation and joint destruction in osteoarthritis rat model: A pilot study

JH Lim, SE Kim, HJ Kim, GG Song, JH Jung - Drug Delivery and …, 2024 - Springer
185 天前 - … localized treatment effectively targets inflammatory aspects … nanoparticles delivered
via intra-articular injections in an OA rat model. Employing mesoporous silica nanomaterials

Synthetic Polymers for Cartilage Uptake and Stimuli-Responsive Hydrogels

J Gong - 2023 - ir.lib.uwo.ca
241 天前 - intra-articular (IA) delivery vehicles are needed to more effectively deliver therapeutics
to their targets in … Osteoarthritis (OA) is the most common type of arthritis and can cause …

Recent advances in porous nanomaterials‐based drug delivery systems for osteoarthritis

S Çitoğlu, H Duran - Nano Select, 2023 - Wiley Online Library
243 天前 - … used in the treatment and administered oral or intra-articular (IA) route to suppress
pain and … [20,26] Therefore, they can be an appropriate choice for treatments targeting the …

[HTML][HTML] Harnessing the multifunctionality of lipid-based drug delivery systems for the local treatment of osteoarthritis

G Bordon, F Berenbaum, O Distler, P Luciani - Biomedicine & …, 2023 - Elsevier
249 天前 - … (DDSs) for intra-articular administration of OA therapeutics, … Liposomes, lipid
nanoparticles, lipidic mesophases, … compared to nanoparticles lacking the targeting peptide and …

Intra-articular injection of stigmasterol loaded nanoparticles is effective in inhibiting joints destruction in an osteoarthritis rat model

JH Lim, SE Kim, HJ Kim, GG Song, JH Jung - 2023 - researchsquare.com
263 天前 - … localized treatment effectively targets inflammatory aspects … nanoparticles delivered
via intra-articular injections in an OA rat model. Employing mesoporous silica nanomaterials