Intrastriatal botulinum toxin abolishes pathologic rotational behaviour and induces axonal varicosities in the 6-OHDA rat model of Parkinson's disease
A Wree, E Mix, A Hawlitschka, V Antipova, M Witt… - Neurobiology of …, 2011 - Elsevier
Central pathophysiological pathways of basal ganglia dysfunction imply a disturbed
interaction of dopaminergic and cholinergic circuits. In Parkinson's disease (PD) imbalanced
cholinergic hyperactivity prevails in the striatum. Interruption of acetylcholine (ACh) release
in the striatum by locally injected botulinum neurotoxin A (BoNT-A) has been studied in the
rat 6-hydroxydopamine (6-OHDA) model of PD (hemi-PD). The hemi-PD was induced by
injection of 6-OHDA into the right medial forebrain bundle. Motor dysfunction provoked by …
interaction of dopaminergic and cholinergic circuits. In Parkinson's disease (PD) imbalanced
cholinergic hyperactivity prevails in the striatum. Interruption of acetylcholine (ACh) release
in the striatum by locally injected botulinum neurotoxin A (BoNT-A) has been studied in the
rat 6-hydroxydopamine (6-OHDA) model of PD (hemi-PD). The hemi-PD was induced by
injection of 6-OHDA into the right medial forebrain bundle. Motor dysfunction provoked by …
[PDF][PDF] Intrastriatal botulinum toxin abolishes pathologic rotational behaviour and induces
O Schmitt, R Benecke - academia.edu
45 A hallmark of Parkinson's disease (PD) is diminished dopaminergic 46 signaling in the
striatum (caudate putamen, CPu), which leads to 47 increased release of acetylcholine
(ACh) by disinhibited tonically 48 active interneurons with the consequence of a disturbed
network 49 function and consecutive motor dysfunction. Current therapeutic 50 strategies
are based on two major approaches in order to correct the 51 disturbed circuits of
involuntary movement control, ie stimulation of 52 dopamine (DA) receptors on GABAergic …
striatum (caudate putamen, CPu), which leads to 47 increased release of acetylcholine
(ACh) by disinhibited tonically 48 active interneurons with the consequence of a disturbed
network 49 function and consecutive motor dysfunction. Current therapeutic 50 strategies
are based on two major approaches in order to correct the 51 disturbed circuits of
involuntary movement control, ie stimulation of 52 dopamine (DA) receptors on GABAergic …