Investigation of mechanisms underlying transient T2 normalization in longitudinal studies of ischemic stroke
SP Lin, RE Schmidt, RC McKinstry… - Journal of Magnetic …, 2002 - Wiley Online Library
Journal of Magnetic Resonance Imaging: An Official Journal of the …, 2002•Wiley Online Library
Purpose To determine if the phenomenon of transient normalization of T2 relaxation in the
subacute stage of ischemic stroke is associated with either magnetic susceptibility effects
secondary to hemorrhage or changes in tissue water content. Materials and Methods We
utilized a rat model of transient, focal, cerebral ischemia. The possibility of hemorrhage was
evaluated with T2*‐weighted (T2* W) imaging and histology. Changes in water content were
assessed by brain wet‐to‐dry weight. Results Susceptibility effects were not evident in T2 …
subacute stage of ischemic stroke is associated with either magnetic susceptibility effects
secondary to hemorrhage or changes in tissue water content. Materials and Methods We
utilized a rat model of transient, focal, cerebral ischemia. The possibility of hemorrhage was
evaluated with T2*‐weighted (T2* W) imaging and histology. Changes in water content were
assessed by brain wet‐to‐dry weight. Results Susceptibility effects were not evident in T2 …
Purpose
To determine if the phenomenon of transient normalization of T2 relaxation in the subacute stage of ischemic stroke is associated with either magnetic susceptibility effects secondary to hemorrhage or changes in tissue water content.
Materials and Methods
We utilized a rat model of transient, focal, cerebral ischemia. The possibility of hemorrhage was evaluated with T2*‐weighted (T2*W) imaging and histology. Changes in water content were assessed by brain wet‐to‐dry weight.
Results
Susceptibility effects were not evident in T2*W images, and neither red blood cells nor unchelated Fe(III) was found in hematoxylin and eosin (H‐E)– or Prussian Blue–stained sections, respectively. However, between the peak of T2 contrast and the point of transient T2 normalization, water content consistently decreased by an average of 3%.
Conclusion
Transient T2 normalization is associated with normalization of water content and can occur without evidence of hemorrhage. J. Magn. Reson. Imaging 2002;15:130–136. © 2002 Wiley‐Liss, Inc.
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