Isolation, structure elucidation, antioxidative and immunomodulatory properties of two novel dihydrocoumarins from Aloe vera
X Zhang, H Wang, Y Song, L Nie, L Wang, B Liu… - Bioorganic & medicinal …, 2006 - Elsevier
Bioorganic & medicinal chemistry letters, 2006•Elsevier
Two new dihydrocoumarin derivatives, compounds 1 and 2, were isolated from Aloe vera.
Their structures were determined by X-ray crystallographic diffraction analysis and extensive
1D, 2D NMR spectroscopic data. Both of them evidently showed antioxidant activity against
superoxide and hydroxyl radicals. Only 1 obviously exhibited immunomodulatory activity in
relation to increasing the phagocytic activity and stimulating the production of superoxide
anions in the oxygen respiratory burst of rat peritoneal macrophages.
Their structures were determined by X-ray crystallographic diffraction analysis and extensive
1D, 2D NMR spectroscopic data. Both of them evidently showed antioxidant activity against
superoxide and hydroxyl radicals. Only 1 obviously exhibited immunomodulatory activity in
relation to increasing the phagocytic activity and stimulating the production of superoxide
anions in the oxygen respiratory burst of rat peritoneal macrophages.
Two new dihydrocoumarin derivatives, compounds 1 and 2, were isolated from Aloe vera. Their structures were determined by X-ray crystallographic diffraction analysis and extensive 1D, 2D NMR spectroscopic data. Both of them evidently showed antioxidant activity against superoxide and hydroxyl radicals. Only 1 obviously exhibited immunomodulatory activity in relation to increasing the phagocytic activity and stimulating the production of superoxide anions in the oxygen respiratory burst of rat peritoneal macrophages.
Elsevier
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