[HTML][HTML] Isotope labeling and biochemical assessment of liver-triacylglycerol in patients with different levels of histologically-graded liver disease
Background Nonalcoholic fatty liver disease (NAFLD) prevalence is rapidly growing, and
fatty liver has been found in a quarter of the US population. Increased liver lipids, particularly
those derived from the pathway of de novo lipogenesis (DNL), have been identified as a
hallmark feature in individuals with high liver fat. This has led to much activity in basic
science and drug development in this area. No studies to date have investigated the
contribution of DNL across a spectrum of disease, although it is clear that inhibition of DNL …
fatty liver has been found in a quarter of the US population. Increased liver lipids, particularly
those derived from the pathway of de novo lipogenesis (DNL), have been identified as a
hallmark feature in individuals with high liver fat. This has led to much activity in basic
science and drug development in this area. No studies to date have investigated the
contribution of DNL across a spectrum of disease, although it is clear that inhibition of DNL …
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