Gig workers face a number of challenges that differ in nature or intensity from those experienced by traditional organizational workers. We developed and tested a measure of six challenges commonly faced by independent workers—viability, organizational, identity, relational, emotional, and career-path uncertainty—in three samples of platform-based workers, including Mechanical Turk workers and highly skilled independent scientists. Initial evidence for the measure’s validity included its convergent and discriminant validity in relation to measures of depletion, thriving, resilience, and loneliness. We confirmed the measure’s factor structure, showed its relationship with thriving and perceived meaningfulness of work, and examined differences across different subgroups in the sample of independent scientists. Our findings help us to better understand the types of stressors independent workers face in the gig economy, and our diverse set of samples provides evidence of the universality of these stressors. Further, our developed measure represents an important research tool for future studies of independent (gig) workers’ experiences."