[HTML][HTML] KEYNOTE-022 part 3: a randomized, double-blind, phase 2 study of pembrolizumab, dabrafenib, and trametinib in BRAF-mutant melanoma

PF Ferrucci, AM Di Giacomo… - … for immunotherapy of …, 2020 - ncbi.nlm.nih.gov
randomized, double-blind, phase 2 part of KEYNOTE-022 compared the efficacy of the triplet
combination of pembrolizumab, dabrafenib, and trametinib … with dabrafenib and trametinib.…

Dabrafenib, trametinib and pembrolizumab or placebo in BRAF-mutant melanoma

PA Ascierto, PF Ferrucci, R Fisher, M Del Vecchio… - Nature medicine, 2019 - nature.com
… conducted the double-blind, randomized, phase 2 part of KEYNOTE-022, … of pembrolizumab,
dabrafenib and trametinib with placebo, … Part 3 of the multicenter phase 1/2 KEYNOTE-022

[HTML][HTML] KEYNOTE-022: Pembrolizumab with trametinib in patients with BRAF wild-type melanoma or advanced solid tumours irrespective of BRAF mutation

M Maio, MS Carlino, AM Joshua, E McWhirter… - European Journal of …, 2022 - Elsevier
… data from the phase 2 SWOG S1320 study, which showed … part 3 of KEYNOTE-022, with a
numerically improved PFS and DOR seen with pembrolizumab plus dabrafenib and trametinib

Randomized Phase III Trial Evaluating Spartalizumab Plus Dabrafenib and Trametinib for BRAF V600–Mutant Unresectable or Metastatic Melanoma

R Dummer, GV Long, C Robert, HA Tawbi… - Journal of Clinical …, 2022 - ascopubs.org
… 1) antibody pembrolizumab in combination with dabrafenib and … of the randomized,
double-blind, placebo-controlled part 3, … -i, the phase II KEYNOTE-022 and phase III IMspire150 …

[HTML][HTML] … plus pembrolizumab triplet therapy in patients with advanced BRAFV600 mutant melanoma: Safety and tolerability results from the phase I IMMU-TARGET …

L Zimmer, E Livingstone, A Krackhardt… - European Journal of …, 2021 - Elsevier
pembrolizumab plus matching placebo), double-blind phase … from the randomised phase II
part of the KEYNOTE-022 trial [… arm of pembrolizumab, dabrafenib and trametinib, compared …

Combined BRAF-targeted therapy with immunotherapy in BRAF-mutated advanced melanoma patients

PF Ferrucci, M Lens, E Cocorocchio - Current oncology reports, 2021 - Springer
… of pembrolizumab in combination with dabrafenib and … advanced melanoma, the randomized,
double-blind part 3 of the trial was … In part 3 of the KEYNOTE-022 trial, 120 patients with …

[HTML][HTML] IMPemBra: a phase 2 study comparing pembrolizumab with intermittent/short-term dual MAPK pathway inhibition plus pembrolizumab in patients with …

EA Rozeman, JM Versluis, K Sikorska… - … for Immunotherapy of …, 2023 - ncbi.nlm.nih.gov
… with pembrolizumab and intermittent dabrafenib and trametinib (p=0.17). The 2-year and 3-…
of the control arm, two of these trials, the COMBI-I and the KEYNOTE-022, did not meet their …

[HTML][HTML] … and cobimetinib in BRAFV600 mutation-positive advanced melanoma (IMspire150): second interim analysis of a multicentre, randomised, phase 3 study

R Dummer, M Welti, E Ramelyte - Journal of Translational Medicine, 2023 - Springer
pembrolizumab combined with BRAF inhibitor dabrafenib … of this study were in concordance
to findings the Keynote-022 trial [11… is a phase 2 study, in which patients were randomized to …

[HTML][HTML] Neoadjuvant pembrolizumab, dabrafenib and trametinib in BRAFV600-mutant resectable melanoma: the randomized phase 2 NeoTrio trial

GV Long, MS Carlino, G Au-Yeung, AJ Spillane… - Nature Medicine, 2024 - nature.com
… Patients were randomized to treatment with 6 weeks of neoadjuvant pembrolizumab … week
of dabrafenib plus trametinib followed by pembrolizumab; n = 20) or concurrent triple therapy (…

Association of BRAF V600E/K mutation status and prior BRAF/MEK inhibition with pembrolizumab outcomes in advanced melanoma: pooled analysis of 3 clinical …

I Puzanov, A Ribas, C Robert, J Schachter… - JAMA …, 2020 - jamanetwork.com
… The randomized, double-blind, phase 2 KEYNOTE-002 study compared … The phase 2
KEYNOTE-022 trial of pembrolizumab plus dabrafenib and trametinib (triplet therapy) in patients …