LINKAGE BETWEEN NOS3 (RS2070744) AND GNB3 (RS5443) GENES'POLYMORPHISM, CAROTID ARTERIES STRUCTURAL CHANGES AND ENDOTHELIAL …
Journal of Hypertension, 2022•journals.lww.com
Objective: This study aims to verify the risk of endothelial dysfunction (ED) and carotid intima
media thickness (IMT) changes depending on GNB3 (rs5443) and NOS3 (rs2070744)
genes' polymorphism in essential arterial hypertensives (EAH). Design and method: One-
hundred EAH patients (moderate-very high cardiovascular risks, aged 45–65 years) and 48
practically healthy (control) participated in the case-control study. Soluble Vascular Cell
Adhesion Molecule (sVCAM-1), total NO metabolites, transcriptional activity of NOS3 gene …
media thickness (IMT) changes depending on GNB3 (rs5443) and NOS3 (rs2070744)
genes' polymorphism in essential arterial hypertensives (EAH). Design and method: One-
hundred EAH patients (moderate-very high cardiovascular risks, aged 45–65 years) and 48
practically healthy (control) participated in the case-control study. Soluble Vascular Cell
Adhesion Molecule (sVCAM-1), total NO metabolites, transcriptional activity of NOS3 gene …
Abstract
Objective:
This study aims to verify the risk of endothelial dysfunction (ED) and carotid intima media thickness (IMT) changes depending on GNB3 (rs5443) and NOS3 (rs2070744) genes’ polymorphism in essential arterial hypertensives (EAH).
Design and method:
One-hundred EAH patients (moderate-very high cardiovascular risks, aged 45–65 years) and 48 practically healthy (control) participated in the case-control study. Soluble Vascular Cell Adhesion Molecule (sVCAM-1), total NO metabolites, transcriptional activity of NOS3 gene, Endothelium-Dependent Flow-Mediated Dilation of the Brachial Artery (FMD BA) and carotid IMT were studied. GNB3 (rs5443) and NOS3 (rs2070744) genotyping performed by TaqMan probes (CFx96ÔReal-Time PCR).
Results:
C-allele of NOS3 gene elevates the risk of atherosclerotic plaques on the carotid arteries over 3.5 times [OR95% CI: 1.24–11.20; p= 0.019 and OR95% CI: 1.22–10.18; p= 0.018], ED–by total NO metabolites decrease (< 25 mol/l) and sVCAM-1 value raise (> 1050 ng/ml)–12 and 4 times [OR95% CI: 1.23–112.7; p= 0.023 and OR95% CI: 1.24–11.20; p= 0.019], respectively. Moreover, C-allele of NOS3 gene heighten the low NOS3 gene expression probability 69 times [OR95% CI: 17, 72–520, 0; p< 0,001].
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