… We show that lactate triggers a signalling pathway that has co-opted the Gpr1 G-protein
coupled receptor and the Crz1 transcription factor from the cAMP and calcineurin signalling …

… signaling and the cAMP-protein kinase pathway. Therefore, hypoxia appears to trigger
immune evasion in this fungal … Previously we showed that lactate-induced β-glucan masking is …

… A recent study demonstrated that lactate-induced masking of β-… immune evasion, thereby
representing an antifungal target [14]. Metabolism of lactate is crucial for β-glucan masking and …

… Our results thus far demonstrate that the XOG1 gene promotes lactate-induced β-glucan
masking and influences immune responses to C. albicans. Next, we confirmed that …

… microbes as well as colonising microbial flora. This is certainly the case for opportunistic …
as to whether cAMP-PKA signalling is required for lactate-induced β-glucan masking. This …

… fungal cell wall epitopes, fungal pathogens have developed mechanisms for immune avoidance
that involve concealing (masking… to induce masking in response to lactate exposure, as …

… Lactate signalling regulates fungal ß-glucan masking and immune evasion. … Candida
albicans hypha formation and mannan masking of beta-glucan inhibit macrophage phagosome …

… fungal immune evasion. For example, the human commensal … display lactate- and
hypoxia-induced β-1,3-glucan masking, … beta-glucan in response to environmental pH is regulated …

… We also highlight the role of fungal cell wall remodeling in epitope masking. … or immune
attack) or increased masking of cell wall β-glucan and chitin (in the case of environmental lactate)…

… in lactate or under hypoxic conditions induces masking of β-… Immune evasion is a powerful
mechanism for commensal … Immune recognition of Candida albicans beta-glucan by dectin…