One of the long-standing challenges in biocatalysis is the search for methods to
continuously regenerate essential cofactors such as NADH that would enable a wide range
of enzymes to be used in the more environmentally friendly synthesis of chiral fine chemicals
including pharmaceuticals, cosmetics, and food additives. This communication reports a
microreactor-based cofactor regeneration method that exploits the microfluidic phenomenon
of laminar flow: a reactant stream and a buffer stream are introduced in a microchannel and …

The concept of a laminar flow-based electrochemical microreactor that utilizes the
occurrence of laminar flow in microfluidic channels to achieve the necessary
compartmentalization of the reductant and oxidant streams in a single channel without a
physical barrier such as a membrane has been introduced. Two specific examples were
explored using laminar flow-based electrochemical microreactors:(i) Membraneless
microfluidic fuel cells in which the fuel and oxidant streams are kept separate by flowing …