Introduction: The spleen is one of the most common solid organs operated by laparoscopic techniques. Laparoscopic splenectomy is one of the most challenging procedure because of the bulk and vascularity of the spleen and wide range of pathological conditions that affect it. The aim of this paper is to report our initial experience with all problems during operation on small number of patient who underwenth laparoscopic menagement due to different splenic pathology. Patients and methods: During the last 3 years (2003-2006) we performed 11 laparoscopic splenectomies for various splenic pathologies (5 patients with Non Hodgkin Lymphoma, 3 with cyst and 3 with ITP). There were 7 females and 4 males with median age 44.8 yrs (18-75). We employed 3 (in 7 cases) and 4 (in 3 cases) trocars technique with right semilateral position. Results: All operations were completed without conversion. Mean splenic size were 18, 6-10.7-5 cm, with the biggest spleen measured at 27-15-5 cm. Splenic vessel were tied in using a vascular Endo-GIA (8 cases), clips (2 case) and" Ligasure&# 8220; sealing system (1 case). The spleen was freed, inserted into endobag and removed. During the operation our biggest problem was inadequate endobag for extraction of spleen. Mean operative time was 150 min; and mean length of hospital stay was 8.1 day. All patient are discharged from hospital without any morbidity. Results: Based on our initial experience, laparoscopic splenectomy is safe and feasible and presents a golden standard for patients with selected benign and malignant splenic pathology.