Large-scale analysis of tandem repeat variability in the human genome
J Duitama, A Zablotskaya, R Gemayel… - Nucleic acids …, 2014 - academic.oup.com
Tandem repeats are short DNA sequences that are repeated head-to-tail with a propensity
to be variable. They constitute a significant proportion of the human genome, also occurring
within coding and regulatory regions. Variation in these repeats can alter the function and/or
expression of genes allowing organisms to swiftly adapt to novel environments. Importantly,
some repeat expansions have also been linked to certain neurodegenerative diseases.
Therefore, accurate sequencing of tandem repeats could contribute to our understanding of …
to be variable. They constitute a significant proportion of the human genome, also occurring
within coding and regulatory regions. Variation in these repeats can alter the function and/or
expression of genes allowing organisms to swiftly adapt to novel environments. Importantly,
some repeat expansions have also been linked to certain neurodegenerative diseases.
Therefore, accurate sequencing of tandem repeats could contribute to our understanding of …
[引用][C] Large-scale analysis of tandem repeat variability in the human genome
A Zablotskaya, J Duitama, R Gemayel, A Jansen… - … ”, Date: 2014/04/24-2014/04 …, 2014