Largest genome-wide association study for PTSD identifies genetic risk loci in European and African ancestries and implicates novel biological pathways
Post-traumatic stress disorder (PTSD) is a common and debilitating disorder. The risk of
PTSD following trauma is heritable, but robust common variants have yet to be identified by
genome-wide association studies (GWAS). We have collected a multi-ethnic cohort
including over 30,000 PTSD cases and 170,000 controls. We first demonstrate significant
genetic correlations across 60 PTSD cohorts to evaluate the comparability of these
phenotypically heterogeneous studies. In this largest GWAS meta-analysis of PTSD to date …
PTSD following trauma is heritable, but robust common variants have yet to be identified by
genome-wide association studies (GWAS). We have collected a multi-ethnic cohort
including over 30,000 PTSD cases and 170,000 controls. We first demonstrate significant
genetic correlations across 60 PTSD cohorts to evaluate the comparability of these
phenotypically heterogeneous studies. In this largest GWAS meta-analysis of PTSD to date …
[引用][C] Largest genome-wide association study for PTSD identifies genetic risk loci in European and African ancestries and implicates novel biological pathways …
CM Nievergelt, AX Maihofer, T Klengel, EG Atkinson… - 2018
以上显示的是最相近的搜索结果。 查看全部搜索结果