Left ventricular noncompaction associated with titin-truncating variants in the TTN gene
YA Vakhrushev, TI Vershinina… - Russian Journal of …, 2020 - russjcardiol.elpub.ru
Aim. To study the association of genetic variants in the titin gene (TTN) with the development
and clinical course of left ventricular noncompaction in different age groups. Material and
methods. The article discusses three clinical cases of patients with left ventricular
noncompaction who were treated at theAlmazovNationalMedicalResearchCenter. We
performed a new-generation sequencing of 108 genes associated with cardiomyopathies,
as well as whole exome sequencing and Sanger sequencing. Results. We identified genetic …
and clinical course of left ventricular noncompaction in different age groups. Material and
methods. The article discusses three clinical cases of patients with left ventricular
noncompaction who were treated at theAlmazovNationalMedicalResearchCenter. We
performed a new-generation sequencing of 108 genes associated with cardiomyopathies,
as well as whole exome sequencing and Sanger sequencing. Results. We identified genetic …
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