2 天前 - … phosphatase that negatively regulates multiple signaling pathways integral to the
… leptin and insulin signaling, which are critical for development of obesity, insulin resistance, …

4 天前 - … , high circulating leptin directly correlates with adiposity, specifically adipocyte
hypertrophy, which in overweight/obese individuals is thought to cause leptin “resistance” in the …

13 天前 - Background Dipeptidyl peptidase 4 (DPP-4) plays a crucial role in breaking down
various substrates. It also has effects on the insulin signaling pathway, contributing to insulin …

21 天前 - … to AAPA, we evaluated whether leptin and adiponectin levels were associated
with … We found that leptin was strongly correlated with all adipose compartments, but not …

29 天前 - … resistance, circulating leptin levels, C-reactive protein levels and risk of severe insulin
resistant … transcription, IL-17 signaling and endocrine resistance. They exhibited negative …

39 天前 - … leptin signaling. Conclusions: Our result unveils a critical role for JMJD3 in the
epigenetic regulation of leptin signaling in … strategy in ameliorating leptin resistance in obesity. …

41 天前 - … This resistance leads to a reduction in the effectiveness of leptin signaling, causing
a … 56 Leptin resistance may also occur in the brain as well as in peripheral tissues and …

48 天前 - … leptin resistance, and suppressing appetite to induce body weight loss, or directly
regulate the changes of fat tissue, etc). Results shows that the acupuncture's regulatory …

49 天前 - … Among hepatic genes upregulated by WSPFE versus controls, were genes
related to insulin-like growth factor binding protein, leptin receptor, and processes of hepatic …

51 天前 - … obesity by directly enhancing leptin signaling. We found that deletion of Sh2b1
in either total or DRN-projecting PVHSH2B1 neurons inhibited BDNF signaling in the PVH. …