Glucose homeostasis is closely regulated not only by insulin, but also by leptin. Both
hormones act centrally, regulating food intake and adiposity in humans. Leptin has several
effects on the glucose-insulin homeostasis, some of which are independent of body weight
and adiposity. Those effects of leptin are determined centrally in the hypothalamus and
peripherally in the pancreas, muscles and liver. Leptin has beneficial effects on the glucose-
insulin metabolism, by decreasing glycemia, insulinemia and insulin resistance. The …