Leukocyte adhesion to P-selectin and the inhibitory role of Crizanlizumab in sickle cell disease: a standardized microfluidic assessment
Upregulated expression of P-selectin on activated endothelium and platelets significantly
contributes to the initiation and progression of vaso-occlusive crises (VOC), a major cause of
morbidity in sickle cell disease (SCD). Crizanlizumab (ADAKVEO®), a humanized
monoclonal antibody against P-selectin, primarily inhibits the interaction between leukocytes
and P-selectin, and has been shown to decrease the frequency of VOCs in clinical trials.
However, the lack of reliable in vitro assays that objectively measure leukocyte adhesion to …
contributes to the initiation and progression of vaso-occlusive crises (VOC), a major cause of
morbidity in sickle cell disease (SCD). Crizanlizumab (ADAKVEO®), a humanized
monoclonal antibody against P-selectin, primarily inhibits the interaction between leukocytes
and P-selectin, and has been shown to decrease the frequency of VOCs in clinical trials.
However, the lack of reliable in vitro assays that objectively measure leukocyte adhesion to …
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