Lineage structure of the human antibody repertoire in response to influenza vaccination
N Jiang, J He, JA Weinstein, L Penland… - Science translational …, 2013 - science.org
The human antibody repertoire is one of the most important defenses against infectious
disease, and the development of vaccines has enabled the conferral of targeted protection
to specific pathogens. However, there are many challenges to measuring and analyzing the
immunoglobulin sequence repertoire, including that each B cell's genome encodes a distinct
antibody sequence, that the antibody repertoire changes over time, and the high similarity
between antibody sequences. We have addressed these challenges by using high …
disease, and the development of vaccines has enabled the conferral of targeted protection
to specific pathogens. However, there are many challenges to measuring and analyzing the
immunoglobulin sequence repertoire, including that each B cell's genome encodes a distinct
antibody sequence, that the antibody repertoire changes over time, and the high similarity
between antibody sequences. We have addressed these challenges by using high …
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