Instability analysis of compressible orthogonal swept leading-edge boundary layer flow was performed in the context of BiGlobal linear theory. 1, 2 An algorithm was developed exploiting the sparsity characteristics of the matrix discretizing the PDE-based eigenvalue problem. This allowed use of the MUMPS sparse linear algebra package3 to obtain a direct solution of the linear systems associated with the Arnoldi iteration. The developed algorithm was then applied to efficiently analyze the effect of compressibility on the stability of the swept leading-edge boundary layer and obtain neutral curves of this flow as a function of the Mach number in the range 0≤ Ma≤ 1. The present numerical results fully confirmed the asymptotic theory results of Theofilis et al. 4 Up to the maximum Mach number value studied, it was found that an increase of this parameter reduces the critical Reynolds number and the range of the unstable spanwise wavenumbers.