Linkage-specific ubiquitin chain formation depends on a lysine hydrocarbon ruler
J Liwocha, DT Krist… - Nature chemical …, 2021 - nature.com
Virtually all aspects of cell biology are regulated by a ubiquitin code where distinct ubiquitin
chain architectures guide the binding events and itineraries of modified substrates. Various
combinations of E2 and E3 enzymes accomplish chain formation by forging isopeptide
bonds between the C terminus of their transiently linked donor ubiquitin and a specific
nucleophilic amino acid on the acceptor ubiquitin, yet it is unknown whether the fundamental
feature of most acceptors—the lysine side chain—affects catalysis. Here, use of synthetic …
chain architectures guide the binding events and itineraries of modified substrates. Various
combinations of E2 and E3 enzymes accomplish chain formation by forging isopeptide
bonds between the C terminus of their transiently linked donor ubiquitin and a specific
nucleophilic amino acid on the acceptor ubiquitin, yet it is unknown whether the fundamental
feature of most acceptors—the lysine side chain—affects catalysis. Here, use of synthetic …
[PDF][PDF] Linkage-specific ubiquitin chain formation depends on a lysine hydrocarbon ruler
VH Truong, O Karayel, N Purser, D Houston, N Burton… - scholarlypublications …
Virtually all aspects of cell biology are regulated by a ubiquitin code where distinct ubiquitin
chain architectures guide the binding events and itineraries of modified substrates. Various
combinations of E2 and E3 enzymes accomplish chain formation by forging isopeptide
bonds between the C terminus of their transiently linked donor ubiquitin and a specific
nucleophilic amino acid on the acceptor ubiquitin, yet it is unknown whether the fundamental
feature of most acceptors—the lysine side chain—affects catalysis. Here, use of synthetic …
chain architectures guide the binding events and itineraries of modified substrates. Various
combinations of E2 and E3 enzymes accomplish chain formation by forging isopeptide
bonds between the C terminus of their transiently linked donor ubiquitin and a specific
nucleophilic amino acid on the acceptor ubiquitin, yet it is unknown whether the fundamental
feature of most acceptors—the lysine side chain—affects catalysis. Here, use of synthetic …
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