[HTML][HTML] Lipids at the crossroad of α-synuclein function and dysfunction: biological and pathological implications
NP Alza, PA Iglesias González, MA Conde… - Frontiers in Cellular …, 2019 - frontiersin.org
Since its discovery, the study of the biological role of α-synuclein and its pathological
implications has been the subject of increasing interest. The propensity to adopt different
conformational states governing its aggregation and fibrillation makes this small 14-kDa
cytosolic protein one of the main etiologic factors associated with degenerative disorders
known as synucleinopathies. The structure, function, and toxicity of α-synuclein and the
possibility of different therapeutic approaches to target the protein have been extensively …
implications has been the subject of increasing interest. The propensity to adopt different
conformational states governing its aggregation and fibrillation makes this small 14-kDa
cytosolic protein one of the main etiologic factors associated with degenerative disorders
known as synucleinopathies. The structure, function, and toxicity of α-synuclein and the
possibility of different therapeutic approaches to target the protein have been extensively …