Recently, a number of studies have demonstrated the potential beneficial role for novel anti-
diabetic GLP-1 receptor agonists (GLP-1RAs) in the skeleton metabolism in diabetic rodents
and patients. In this study, we evaluated the impacts of the synthetic GLP-1RA Liraglutide on
bone mass and quality in osteoporotic rats induced by ovariectomy (OVX) but without
diabetes, as well as its effect on the adipogenic and osteoblastogenic differentiation of bone
marrow stromal cells (BMSCs). Three months after sham surgery or bilateral OVX, eighteen …

The article focuses on a study which aims to evaluate the changes in bone mineral density
(BMD) and bone micro-architecture in spontaneous diabetic Goto-Kakizaki (GK) rats that
receive daily administration of liraglutide. Studies reveal the effectiveness of liraglutide, a
glucagon-like peptide-1 (GLP-1) receptor agonist (GLP-1RA), in treating diabetes.
Information about functional receptors for GLP-1, which are expressed on osteoblasts, is
presented.