Long‐term adaptation of global transcription and metabolism in the liver of high‐fat diet‐fed C57BL/6J mice
GM Do, HY Oh, EY Kwon, Y Cho, S Shin… - Molecular nutrition & …, 2011 - Wiley Online Library
Scope: This study investigated the global transcriptional and metabolic changes occurring at
multiple time points over 24 wk in response to a high‐fat diet (HFD). Methods and results:
C57BL/6J mice were fed a HFD or normal diet (ND) over 24 wk. HFD‐fed mice developed
early clinical indicators of obesity‐related co‐morbidities including fatty liver, insulin
resistance, hyperglycemia and hypercholesterolemia. Time‐course microarray analysis at
eight time points over 24 wk identified 332 HFD responsive genes as potential targets to …
multiple time points over 24 wk in response to a high‐fat diet (HFD). Methods and results:
C57BL/6J mice were fed a HFD or normal diet (ND) over 24 wk. HFD‐fed mice developed
early clinical indicators of obesity‐related co‐morbidities including fatty liver, insulin
resistance, hyperglycemia and hypercholesterolemia. Time‐course microarray analysis at
eight time points over 24 wk identified 332 HFD responsive genes as potential targets to …
Long-term adaptation of global transcription and metabolism in the liver of high-fat diet-fed C57BL/6J mice.
DGM Do GyeongMin, OHY Oh HeaYoung… - 2011 - cabidigitallibrary.org
Scope: This study investigated the global transcriptional and metabolic changes occurring at
multiple time points over 24 wk in response to a high-fat diet (HFD). Methods and results:
C57BL/6J mice were fed a HFD or normal diet (ND) over 24 wk. HFD-fed mice developed
early clinical indicators of obesity-related co-morbidities including fatty liver, insulin
resistance, hyperglycemia and hypercholesterolemia. Time-course microarray analysis at
eight time points over 24 wk identified 332 HFD responsive genes as potential targets to …
multiple time points over 24 wk in response to a high-fat diet (HFD). Methods and results:
C57BL/6J mice were fed a HFD or normal diet (ND) over 24 wk. HFD-fed mice developed
early clinical indicators of obesity-related co-morbidities including fatty liver, insulin
resistance, hyperglycemia and hypercholesterolemia. Time-course microarray analysis at
eight time points over 24 wk identified 332 HFD responsive genes as potential targets to …
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