Recent studies highlighted long noncoding RNAs (lncRNAs) to play an important role in
cardiac development. However, understanding of lncRNAs in cardiac diseases is still
limited. Global lncRNA expression profiling indicated that several lncRNA transcripts are
deregulated during pressure overload–induced cardiac hypertrophy in mice. Using stringent
selection criteria, we identified Chast (cardiac hypertrophy–associated transcript) as a
potential lncRNA candidate that influences cardiomyocyte hypertrophy. Cell fractionation …