Long-term effects of a high-protein, low-carbohydrate diet on weight control and cardiovascular risk markers in obese hyperinsulinemic subjects
International Journal of Obesity, 2004•nature.com
OBJECTIVE: To compare the long-term compliance and effects of two low-fat diets differing
in carbohydrate to protein ratio on body composition and biomarkers of cardiovascular
disease risk in obese subjects with hyperinsulinemia. DESIGN: Outpatient, parallel, clinical
intervention study of two groups of subjects randomly assigned to either a standard protein
(SP; 15% protein, 55% carbohydrate) or high-protein (HP; 30% protein, 40% carbohydrate)
diet, during 12 weeks of energy restriction (∼ 6.5 MJ/day) and 4 weeks of energy balance …
in carbohydrate to protein ratio on body composition and biomarkers of cardiovascular
disease risk in obese subjects with hyperinsulinemia. DESIGN: Outpatient, parallel, clinical
intervention study of two groups of subjects randomly assigned to either a standard protein
(SP; 15% protein, 55% carbohydrate) or high-protein (HP; 30% protein, 40% carbohydrate)
diet, during 12 weeks of energy restriction (∼ 6.5 MJ/day) and 4 weeks of energy balance …
Abstract
OBJECTIVE: To compare the long-term compliance and effects of two low-fat diets differing in carbohydrate to protein ratio on body composition and biomarkers of cardiovascular disease risk in obese subjects with hyperinsulinemia.
DESIGN: Outpatient, parallel, clinical intervention study of two groups of subjects randomly assigned to either a standard protein (SP; 15% protein, 55% carbohydrate) or high-protein (HP; 30% protein, 40% carbohydrate) diet, during 12 weeks of energy restriction (∼ 6.5 MJ/day) and 4 weeks of energy balance (∼ 8.3 MJ/day). Subsequently, subjects were asked to maintain the same dietary pattern for the succeeding 52 weeks with minimal professional support.
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