Background Mediterranean and low-fat diets are effective in the primary prevention of
cardiovascular disease. We did a long-term randomised trial to compare the effects of these
two diets in secondary prevention of cardiovascular disease. Methods The CORDIOPREV
study was a single-centre, randomised clinical trial done at the Reina Sofia University
Hospital in Córdoba, Spain. Patients with established coronary heart disease (aged 20–75
years) were randomly assigned in a 1: 1 ratio by the Andalusian School of Public Health to …

The CORDIOPREV trial compared the use of Mediterranean and low-fat diets for secondary
prevention of CVD. 1002 patients aged 20–75 years (mean 59.5 years, 82.5% male) with
established CHD were randomised 1: 1 to receive a Mediterranean diet or a low-fat diet
intervention, with a follow-up of 7 years. The primary outcome was a composite of major
cardiovascular events, including myocardial infarction, revascularisation, ischaemic stroke,
peripheral arterial disease, and cardiovascular death. During follow-up, the primary end …