Loss of MicroRNA-192 promotes fibrogenesis in diabetic nephropathy
A Krupa, R Jenkins, DD Luo, A Lewis… - Journal of the …, 2010 - journals.lww.com
The role of microRNAs (miRs), which are endogenous RNA oligonucleotides that regulate
gene expression, in diabetic nephropathy is unknown. Here, we performed expression
profiling of cultured proximal tubular cells (PTCs) under high-glucose and control conditions.
We identified expression of 103 of 328 microRNAs but did not observe glucose-induced
changes in expression. Next, we performed miR expression profiling in pooled RNA from
formalin-fixed, paraffin-embedded tissue from renal biopsies. We studied three groups of …
gene expression, in diabetic nephropathy is unknown. Here, we performed expression
profiling of cultured proximal tubular cells (PTCs) under high-glucose and control conditions.
We identified expression of 103 of 328 microRNAs but did not observe glucose-induced
changes in expression. Next, we performed miR expression profiling in pooled RNA from
formalin-fixed, paraffin-embedded tissue from renal biopsies. We studied three groups of …
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