… , we demonstrate that iNOS gene expression of human chondrocytes is regulated at the …
expression is mediated by the binding of NF-κB to the upstream sites of iNOS enhancer elements…

… loss of methylation that occurs at specific CpG sites localised at the −5.8 kb NF-κB enhancer
region of the iNOS gene … This catabolic factor is the product of inducible nitric oxide synthase …

… CpG sites of selected candidate hypomethylated genes: … participates in the NF-κB pathway
[18]. High levels of TRAF1 … ultimately to complete loss of articular cartilage. Previous studies …

… bone remodeling resulting in a loss of joint function. These … E synthase-1 (mPGES-1),
inducible nitric oxide synthase (iNOS), … , articular cartilage is composed of two main elements: the …

… methylated CpG sites near or within OA-related genes [2,3]. It … ), nor chondrocyte
dedifferentiation, as evidenced by lack of … that this hypermethylation was responsible for the …

… via nitric oxide (NO), since NO donors also caused gene … However, there were CpG sites,
where loss of methylation … proteases that are induced in OA have NF-κB binding sites in their …

… ) and Nitric Oxide Synthase (NOS… loss of methylation at specific CpG sites in the iNOS
promoter could not account for its abnormal expression; however, demethylation of specific NF-κB …

… Loss of methylation in CpG sites in the NF-κB enhancer elements of inducible nitric oxide
synthase is responsible for gene induction in human articular chondrocytes. Arthritis Rheum …

… Similarly, the CpG sites within the promoter area of a number of … an NF-κB-responsive
enhancer was shown to increase the expression of inducible nitric oxide synthase (iNOS), a gene …

… results in enhanced expression of IL8 and loss of DNA methylation … methylation of specific
CpG sites correlates with IL8 gene … the NF-κB p65 subunit played a critical role in induction of …