Loss of protease-activated receptor 4 prevents inflammation resolution and predisposes the heart to cardiac rupture after myocardial infarction
MA Kolpakov, X Guo, K Rafiq, L Vlasenko… - Circulation, 2020 - Am Heart Assoc
Background: Cardiac rupture is a major lethal complication of acute myocardial infarction
(MI). Despite significant advances in reperfusion strategies, mortality from cardiac rupture
remains high. Studies suggest that cardiac rupture can be accelerated by thrombolytic
therapy, but the relevance of this risk factor remains controversial. Methods: We analyzed
protease-activated receptor 4 (Par4) expression in mouse hearts with MI and investigated
the effects of Par4 deletion on cardiac remodeling and function after MI by …
(MI). Despite significant advances in reperfusion strategies, mortality from cardiac rupture
remains high. Studies suggest that cardiac rupture can be accelerated by thrombolytic
therapy, but the relevance of this risk factor remains controversial. Methods: We analyzed
protease-activated receptor 4 (Par4) expression in mouse hearts with MI and investigated
the effects of Par4 deletion on cardiac remodeling and function after MI by …
[PDF][PDF] Loss of Protease-Activated Receptor 4 Prevents Inflammation Resolution and Predisposes the Heart to Cardiac Rupture after Myocardial Infarction
A Sabri - researchgate.net
Background: Cardiac rupture is a major lethal complication of acute myocardial infarction
(MI). Despite significant advances in reperfusion strategies, mortality from cardiac rupture
remains high. Studies suggest that cardiac rupture can be accelerated by thrombolytic
therapy, but the relevance of this risk factor remains controversial. Methods: We analyzed
protease activated receptor (Par) 4 expression in mouse hearts with MI and investigated the
effects of Par4 deletion on cardiac remodeling and function post-MI by echocardiography …
(MI). Despite significant advances in reperfusion strategies, mortality from cardiac rupture
remains high. Studies suggest that cardiac rupture can be accelerated by thrombolytic
therapy, but the relevance of this risk factor remains controversial. Methods: We analyzed
protease activated receptor (Par) 4 expression in mouse hearts with MI and investigated the
effects of Par4 deletion on cardiac remodeling and function post-MI by echocardiography …
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