Low NT-proBNP levels: An early sign for the diagnosis of ischemic heart failure
Y Zheng, L Ye, X Cen, J Lin, J Fu, L Wang - International Journal of …, 2017 - Elsevier
Y Zheng, L Ye, X Cen, J Lin, J Fu, L Wang
International Journal of Cardiology, 2017•ElsevierBackground N-terminal pro-brain natriuretic peptide (NT-proBNP) is seen to be mostly
elevated in patients with acute heart failure (AHF). However, cases of AHF presenting with
low NT-proBNP levels have been reported. In this study designed to investigate the factors
associated with low NT-proBNP levels in AHF patients, we discovered that etiology and
related factors have an influence on NT-proBNP levels. Methods In this study, 154 AHF
patients met the study criteria (117 men, median age 74 years; left ventricular ejection …
elevated in patients with acute heart failure (AHF). However, cases of AHF presenting with
low NT-proBNP levels have been reported. In this study designed to investigate the factors
associated with low NT-proBNP levels in AHF patients, we discovered that etiology and
related factors have an influence on NT-proBNP levels. Methods In this study, 154 AHF
patients met the study criteria (117 men, median age 74 years; left ventricular ejection …
Background
N-terminal pro-brain natriuretic peptide (NT-proBNP) is seen to be mostly elevated in patients with acute heart failure (AHF). However, cases of AHF presenting with low NT-proBNP levels have been reported. In this study designed to investigate the factors associated with low NT-proBNP levels in AHF patients, we discovered that etiology and related factors have an influence on NT-proBNP levels.
Methods
In this study, 154 AHF patients met the study criteria (117 men, median age 74 years; left ventricular ejection fraction [LVEF] 46 ± 13%; New York Heart Association [NYHA] classes II–IV). We analyzed the different clinical variables of patients based on plasma NT-proBNP levels. In addition, we identified the differences in NT-proBNP levels between ischemic and non-ischemic etiologies, as well as the relationships between time from symptom onset to ED visit and NT-proBNP levels.
Results
The group with low NT-proBNP levels showed an ischemic association, higher LVEF, lower NYHA class and shorter time from symptom onset to ED visit. Plasma NT-proBNP levels were lower in the ischemic group than in the non-ischemic group (P < 0.01). Meanwhile, NT-proBNP levels were relatively low in patients during early phases of AHF hospitalization and increased with time from symptom onset to ED visit (P < 0.01).
Conclusion
We inferred that low NT-proBNP levels may infer the ischemic etiology especially in patients with normal LVEF in the early phases of AHF hospitalization.
Elsevier
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