Lsr2 and its novel paralogue mediate the adjustment of Mycobacterium smegmatis to unfavorable environmental conditions
M Kołodziej, T Łebkowski, P Płociński, J Hołówka… - Msphere, 2021 - Am Soc Microbiol
Lsr2 is a nucleoid-associated protein (NAP) that has been found strictly in actinobacteria,
including mycobacteria. It is a functional homolog of histone-like nucleoid-structuring protein
(H-NS); it acts as a DNA-bridging protein that plays a role in chromosomal organization and
transcriptional regulation. To date, the studies on Lsr2 have focused mainly on
Mycobacterium tuberculosis. In this study, we analyze the role of Lsr2 as a transcription
factor in Mycobacterium smegmatis, a saprophytic bacterium whose natural habitat (soil and …
including mycobacteria. It is a functional homolog of histone-like nucleoid-structuring protein
(H-NS); it acts as a DNA-bridging protein that plays a role in chromosomal organization and
transcriptional regulation. To date, the studies on Lsr2 have focused mainly on
Mycobacterium tuberculosis. In this study, we analyze the role of Lsr2 as a transcription
factor in Mycobacterium smegmatis, a saprophytic bacterium whose natural habitat (soil and …
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