[PDF][PDF] Lupeol targets liver tumor‐initiating cells through phosphatase and tensin homolog modulation
Liver tumor‐initiating cells (T‐ICs) are capable of self‐renewal and tumor initiation and are
more chemoresistant to chemotherapeutic drugs. The current therapeutic strategies for
targeting stem cell self‐renewal pathways therefore represent rational approaches for
cancer prevention and treatment. In the present study, we found that Lup‐20 (29)‐en‐3β‐ol
(lupeol), a triterpene found in fruits and vegetables, inhibited the self‐renewal ability of liver
T‐ICs present in both hepatocellular carcinoma (HCC) cell lines and clinical HCC samples …
more chemoresistant to chemotherapeutic drugs. The current therapeutic strategies for
targeting stem cell self‐renewal pathways therefore represent rational approaches for
cancer prevention and treatment. In the present study, we found that Lup‐20 (29)‐en‐3β‐ol
(lupeol), a triterpene found in fruits and vegetables, inhibited the self‐renewal ability of liver
T‐ICs present in both hepatocellular carcinoma (HCC) cell lines and clinical HCC samples …
Lupeol targets liver tumor-initiating cells through phosphatase and tensin homolog modulation.
KWT Lee KinWah [Lee, A Castilho… - 2011 - cabidigitallibrary.org
Liver tumor-initiating cells (T-ICs) are capable of self-renewal and tumor initiation and are
more chemoresistant to chemotherapeutic drugs. The current therapeutic strategies for
targeting stem cell self-renewal pathways therefore represent rational approaches for cancer
prevention and treatment. In the present study, we found that Lup-20 (29)-en-3β-ol (lupeol),
a triterpene found in fruits and vegetables, inhibited the self-renewal ability of liver T-ICs
present in both hepatocellular carcinoma (HCC) cell lines and clinical HCC samples, as …
more chemoresistant to chemotherapeutic drugs. The current therapeutic strategies for
targeting stem cell self-renewal pathways therefore represent rational approaches for cancer
prevention and treatment. In the present study, we found that Lup-20 (29)-en-3β-ol (lupeol),
a triterpene found in fruits and vegetables, inhibited the self-renewal ability of liver T-ICs
present in both hepatocellular carcinoma (HCC) cell lines and clinical HCC samples, as …