The mechanisms by which breast cancers progress from relatively indolent ductal carcinoma
in situ (DCIS) to invasive ductal carcinoma (IDC) are not well understood. However, this
process is critical to the acquisition of metastatic potential. MAPK-interacting
serine/threonine-protein kinase 1 (MNK1) signaling can promote cell invasion. NODAL, a
morphogen essential for embryogenic patterning, is often reexpressed in breast cancer.
Here we describe a MNK1/NODAL signaling axis that promotes DCIS progression to IDC …

In the original version of this article (1), there were errors in Fig. 1B. Specifically, for
lowgrade DCIS, the percentage of samples with high phospho-MNK1 should be
7.7%(instead of 8.8%), and for low phospho-MNK1, it should read 92.3%(instead of 91.7%).
In addition, for high-grade DCIS, the percentage of samples with high phospho-MNK1
should be 55.6%(instead of 55%), and for low phospho-MNK1, it should read 44.4%(instead
of 45%). The incorrect percentages were also used in the Results section when describing …