Our knowledge of the fundamental particles of nature and their interactions is summarized by the standard model of particle physics. Advancing our understanding in this field has required experiments that operate at ever higher energies and intensities, which produce extremely large and information-rich data samples. The use of machine-learning techniques is revolutionizing how we interpret these data samples, greatly increasing the discovery potential of present and future experiments. Here we summarize the challenges and opportunities that come with the use of machine learning at the frontiers of particle physics.