Macrophage autophagy in immunity to Cryptococcus neoformans and Candida albicans

AM Nicola, P Albuquerque, LR Martinez… - Infection and …, 2012 - Am Soc Microbiol
Autophagy is used by eukaryotes in bulk cellular material recycling and in immunity to
intracellular pathogens. We evaluated the role of macrophage autophagy in the response to
Cryptococcus neoformans and Candida albicans, two important opportunistic fungal
pathogens. The autophagosome marker LC3 (microtubule-associated protein 1 light chain 3
alpha) was present in most macrophage vacuoles containing C. albicans. In contrast, LC3
was found in only a few vacuoles containing C. neoformans previously opsonized with …

Macrophage Autophagy in Immunity to Cryptococcus neoformans and Candida albicans

M De Jesus - 2012 - scholarsarchive.library.albany.edu
Autophagy is used by eukaryotes in bulk cellular material recycling and in immunity to
intracellular pathogens. We evaluated the role of macrophage autophagy in the response to
Cryptococcus neoformans and Candida albicans, two important opportunistic fungal
pathogens. The autophagosome marker LC3 (microtubule-associated protein 1 light chain 3
alpha) was present in most macrophage vacuoles containing C. albicans. In contrast, LC3
was found in only a few vacuoles containing C. neoformans previously opsonized with …
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