Macrophage-specific nanotechnology-driven CD163 overexpression in human macrophages results in an M2 phenotype under inflammatory conditions
M1 macrophages release proinflammatory factors during inflammation. They transit to an M2
phenotype and release anti-inflammatory factors to resolve inflammation. An imbalance in
the transition from M1 to M2 phenotype in macrophages contributes to the development of
persistent inflammation. CD163, a member of the scavenger receptor cysteine-rich family, is
an M2 macrophage marker. The functional role of CD163 during the resolution of
inflammation is not completely known. We postulate that CD163 contributes to the transition …
phenotype and release anti-inflammatory factors to resolve inflammation. An imbalance in
the transition from M1 to M2 phenotype in macrophages contributes to the development of
persistent inflammation. CD163, a member of the scavenger receptor cysteine-rich family, is
an M2 macrophage marker. The functional role of CD163 during the resolution of
inflammation is not completely known. We postulate that CD163 contributes to the transition …
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