[HTML][HTML] Malaria preventive therapy in pregnancy and its potential impact on immunity to malaria in an area of declining transmission
Malaria Journal, 2015•Springer
Background Regular anti-malarial therapy in pregnancy, a pillar of malaria control, may
affect malaria immunity, with therapeutic implications in regions of reducing transmission.
Methods Plasma antibodies to leading vaccine candidate merozoite antigens and
opsonizing antibodies to endothelial-binding and placental-binding infected erythrocytes
were quantified in pregnant Melanesian women receiving sulfadoxine-pyrimethamine (SP)
with chloroquine taken once, or three courses of SP with azithromycin. Results Malaria …
affect malaria immunity, with therapeutic implications in regions of reducing transmission.
Methods Plasma antibodies to leading vaccine candidate merozoite antigens and
opsonizing antibodies to endothelial-binding and placental-binding infected erythrocytes
were quantified in pregnant Melanesian women receiving sulfadoxine-pyrimethamine (SP)
with chloroquine taken once, or three courses of SP with azithromycin. Results Malaria …
Background
Regular anti-malarial therapy in pregnancy, a pillar of malaria control, may affect malaria immunity, with therapeutic implications in regions of reducing transmission.
Methods
Plasma antibodies to leading vaccine candidate merozoite antigens and opsonizing antibodies to endothelial-binding and placental-binding infected erythrocytes were quantified in pregnant Melanesian women receiving sulfadoxine-pyrimethamine (SP) with chloroquine taken once, or three courses of SP with azithromycin.
Results
Malaria prevalence was low. Between enrolment and delivery, antibodies to recombinant antigens declined in both groups (p < 0.0001). In contrast, median levels of opsonizing antibodies did not change, although levels for some individuals changed significantly. In multivariate analysis, the malaria prevention regimen did not influence antibody levels.
Conclusion
Different preventive anti-malarial chemotherapy regimens used during pregnancy had limited impact on malarial-immunity in a low-transmission region of Papua New Guinea.
Trial registrations
NCT01136850
Springer
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