Malat-1-PRC2-EZH1 interaction supports adaptive oxidative stress dependent epigenome remodeling in skeletal myotubes
PRC2-mediated epigenetic function involves the interaction with long non-coding RNAs
(lncRNAs). Although the identity of some of these RNAs has been elucidated in the context
of developmental programs, their counterparts in postmitotic adult tissue homeostasis
remain uncharacterized. To this aim, we used terminally differentiated postmitotic skeletal
muscle cells in which oxidative stress induces the dynamic activation of PRC2-Ezh1 through
Embryonic Ectoderm Develpment (EED) shuttling to the nucleus. We identify lncRNA Malat …
(lncRNAs). Although the identity of some of these RNAs has been elucidated in the context
of developmental programs, their counterparts in postmitotic adult tissue homeostasis
remain uncharacterized. To this aim, we used terminally differentiated postmitotic skeletal
muscle cells in which oxidative stress induces the dynamic activation of PRC2-Ezh1 through
Embryonic Ectoderm Develpment (EED) shuttling to the nucleus. We identify lncRNA Malat …
以上显示的是最相近的搜索结果。 查看全部搜索结果