Unlike neurons in the central nervous system (CNS), injured neurons in the peripheral
nervous system (PNS) can regenerate their axons and reinnervate their targets. However,
functional recovery in the PNS often remains suboptimal, especially in cases of severe
damage. The lack of regenerative ability of CNS neurons has been linked to down-
regulation of the mTOR (mammalian target of rapamycin) pathway. We report here that PNS
dorsal root ganglial neurons (DRGs) activate mTOR following damage and that this activity …