Management of Liddle syndrome in pregnancy: a case report and literature review
M Awadalla, M Patwardhan… - Case Reports in …, 2017 - Wiley Online Library
Case Reports in Obstetrics and Gynecology, 2017•Wiley Online Library
Liddle syndrome is an autosomal dominant genetic condition that causes hypertension and
hypokalemia due to a gain‐of‐function mutation in the SCNN1B or SCNN1G genes which
code for the epithelial sodium channel in the kidney. This leads to increased sodium and
water reabsorption causing hypertension. We report a case of a 27‐year‐old pregnant
woman who was admitted for hypertension and hypokalemia and later diagnosed and
treated for Liddle syndrome using amiloride. Maintaining a high suspicion of Liddle …
hypokalemia due to a gain‐of‐function mutation in the SCNN1B or SCNN1G genes which
code for the epithelial sodium channel in the kidney. This leads to increased sodium and
water reabsorption causing hypertension. We report a case of a 27‐year‐old pregnant
woman who was admitted for hypertension and hypokalemia and later diagnosed and
treated for Liddle syndrome using amiloride. Maintaining a high suspicion of Liddle …
Liddle syndrome is an autosomal dominant genetic condition that causes hypertension and hypokalemia due to a gain‐of‐function mutation in the SCNN1B or SCNN1G genes which code for the epithelial sodium channel in the kidney. This leads to increased sodium and water reabsorption causing hypertension. We report a case of a 27‐year‐old pregnant woman who was admitted for hypertension and hypokalemia and later diagnosed and treated for Liddle syndrome using amiloride. Maintaining a high suspicion of Liddle syndrome in pregnancy is essential in such cases to be able to adequately and effectively treat the hypertension. Due to physiological effects of pregnancy, the dose of amiloride may need to be increased as gestational age progresses up to a maximum dose of 30 mg orally per day.
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