Marine alkaloid pityriacitrin and its analogues: discovery, structures, synthetic methods and biological properties

S Ke, T Xu, Y Min, Z Wan, Z Yang… - Mini Reviews in …, 2021 - ingentaconnect.com
S Ke, T Xu, Y Min, Z Wan, Z Yang, K Wang
Mini Reviews in Medicinal Chemistry, 2021ingentaconnect.com
Pityriacitrin is a natural marine alkaloid with a typical β-carboline scaffold, and which has
been demonstrated to exhibit diverse biological functions. The special structural features for
pityriacitrin lead to the increasing research interest and the emergence of versatile
derivatives, and many pityriacitrin analogues have been isolated or synthesized over the
past decades. The structural diversity and evolved biological activity of these natural
alkaloids can offer opportunities for the development of highly potential novel drugs with a …
Pityriacitrin is a natural marine alkaloid with a typical β-carboline scaffold, and which has been demonstrated to exhibit diverse biological functions. The special structural features for pityriacitrin lead to the increasing research interest and the emergence of versatile derivatives, and many pityriacitrin analogues have been isolated or synthesized over the past decades. The structural diversity and evolved biological activity of these natural alkaloids can offer opportunities for the development of highly potential novel drugs with a new mechanism of action, and therefore, the aim of this brief review is to describe the discovery, synthesis, and biological properties of natural pityriacitrin and its derivatives, as well as the isolation source.
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