Matching protein interfaces for improved medium-chain fatty acid production
Medium-chain fatty acids (MCFAs) are key intermediates in the synthesis of medium-chain
chemicals including α-olefins and dicarboxylic acids. In bacteria, microbial production of
MCFAs is limited by the activity and product profile of fatty acyl-ACP thioesterases. Here, we
engineer a heterologous bacterial medium-chain fatty acyl-ACP thioesterase for improved
MCFA production in Escherichia coli. Electrostatically matching the interface between the
heterologous medium-chain Acinetobacter baylyi fatty acyl-ACP thioesterase (AbTE) and the …
chemicals including α-olefins and dicarboxylic acids. In bacteria, microbial production of
MCFAs is limited by the activity and product profile of fatty acyl-ACP thioesterases. Here, we
engineer a heterologous bacterial medium-chain fatty acyl-ACP thioesterase for improved
MCFA production in Escherichia coli. Electrostatically matching the interface between the
heterologous medium-chain Acinetobacter baylyi fatty acyl-ACP thioesterase (AbTE) and the …
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