Maternal nutrition at conception modulates DNA methylation of human metastable epialleles
P Dominguez-Salas, SE Moore, MS Baker… - Nature …, 2014 - nature.com
In experimental animals, maternal diet during the periconceptional period influences the
establishment of DNA methylation at metastable epialleles in the offspring, with permanent
phenotypic consequences. Pronounced naturally occurring seasonal differences in the diet
of rural Gambian women allowed us to test this in humans. We show that significant
seasonal variations in methyl-donor nutrient intake of mothers around the time of conception
influence 13 relevant plasma biomarkers. The level of several of these maternal biomarkers …
establishment of DNA methylation at metastable epialleles in the offspring, with permanent
phenotypic consequences. Pronounced naturally occurring seasonal differences in the diet
of rural Gambian women allowed us to test this in humans. We show that significant
seasonal variations in methyl-donor nutrient intake of mothers around the time of conception
influence 13 relevant plasma biomarkers. The level of several of these maternal biomarkers …
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