… also low abundance, the study of matrilins is cumbersome. In this chapter, … matrilins from
tissue, analysis of matrilins in tissue extracts, recombinant expression, and generation of matrilin…

… The number of EGF repeats varies between one in matrilin-1 and 10 in matrilin-2. While
matrilin-3 and mouse matrilin-4 always contain four EGF-like domains, human matrilin-4 occurs …

… matrilins bind weakly to α1β1 integrin and cell surface proteoglycans, but even though matrilins
play a role in mechanotransduction and matrilin-3 … of matrilin-cell interactions is unclear. …

… Attempts to study matrilin function by gene inactivation in mouse … matrilin-3 in humans cause
different forms of chondrodysplasias and perhaps also hand osteoarthritis. As loss of matrilin…

… a slight decrease in matrilin-4 binding. This indicates that impaired binding of COMP to
matrilins does not cause the pseudoachondroplasia phenotype but rather that matrilins may be …

… within genomic regions syntenic to those of tetrapod matrilins (Figure 6A). MATN2 is … that
fish matrilin-3s should be encoded within a genomic region similar to that of tetrapod matrilin-3 …

… Since 1996 three further members have been found: matrilin-2 3,-3 4, 5 and-4 6. Alignment
of the matrilin sequences shows a strong similarity between all the proteins. The matrilins can …

… is vital for the secretion of matrilin-3. Secretion of the mutant matrilin-3 harbouring a point
mutation … , resulting from intracellular retention of the mutant matrilin-3. Taken together, our data …

… Matrilin 1 and matrilin 3 are expressed in cartilage, while matrilin 2 and matrilin 4 are …
carrying a null mutation in the Crtm gene encoding matrilin 1. Anatomical and histological studies …

Matrilin-2 is a member of the protein superfamily with von Willebrand factor type A-like modules.
Mouse matrilin-2 … The affinity-purified antiserum detects matrilin-2 in dense and loose …