Mechanical force modulates development, influences tissue homeostasis, and contributes to
disease. Forces sculpt tissue-level behaviors and direct cell fate by engaging
mechanoreceptors and by altering organization of the cytoskeleton and actomyosin
contractility to stimulate mechanotransduction mechanisms that alter transcription.
Nevertheless, how force specifically leverages mechanotransduction pathways to control
transcriptional regulation of cell fate remains unclear. Here we review recent findings …