… In summary, several mechanisms initiate liver cell damage and aggravate ongoing injury
processes. Mitochondria are prominent targets for the hepatotoxicity of many drugs. …

Drug-induced hepatotoxicity (DIH) is an important clinical problem in the United States and
around the world. It is one of the primary reasons for failure of drug candidates during …

… mechanisms). Ultimately, it is the balance between bioactivation, detoxification and defense
mechanisms … Studies on hepatotoxicity most frequently deal with a type of cell death which is …

… model that limits its principle mechanisms to three main ways of … For all mechanisms,
mitochondria play a central role in … a better understanding of mechanisms in hepatotoxicity, and to …

… Toxic liver disease, hepatotoxicity, encompasses numerous … to detection and assessment of
hepatotoxicity induced by human … detection requirements of hepatotoxicity caused by natural …

… understand the mechanism (s) and to establish their correlation with in vivo hepatotoxicity
(… The current review focus and discuss on probable mechanism(s) of hepatotoxicity due to …

Severe and prolonged impairment of mitochondrial β-oxidation leads to microvesicular
steatosis, and, in severe forms, to liver failure, coma and death. Impairment of mitochondrial β-…

… accounting for global hepatotoxicity and mechanisms-related … predominant mechanisms
of toxicity and 18 non-hepatotoxic … signatures for each mechanism of hepatotoxicity. The …

… in the United States and mechanisms of liver injury induced by … , have shown that hepatotoxicity
is initiated by formation of a … the mechanisms behind APAP-induced hepatotoxicity and …

… to understand the mechanisms underlying the idiosyncratic … may suggest a mechanism for
the hepatotoxicity induced by this … in predicting idiosyncratic hepatotoxicity. Supplementary …