Oxysterols are oxidation products of cholesterol that are generated by enzymatic reactions
mediated by cytochrome P450 family enzymes or by non-enzymatic reactions involving
reactive oxygen and nitrogen species. Oxysterols play various regulatory roles in normal
cellular processes such as cholesterol homeostasis by acting as intermediates in cholesterol
catabolism. Pathological effects of oxysterols have also been described, and various reports
have implicated oxysterols in several disease states, including atherosclerosis, neurological …