Mechanisms of slower nitric oxide uptake by red blood cells and other hemoglobin-containing vesicles
Nitric oxide (NO) acts as a smooth muscle relaxation factor and plays a crucial role in
maintaining vascular homeostasis. NO is scavenged rapidly by hemoglobin (Hb). However,
under normal physiological conditions, the encapsulation of Hb inside red blood cells
(RBCs) significantly retards NO scavenging, permitting NO to reach the smooth muscle. The
rate-limiting factors (diffusion of NO to the RBC surface, through the RBC membrane or
inside of the RBC) responsible for this retardation have been the subject of much debate …
maintaining vascular homeostasis. NO is scavenged rapidly by hemoglobin (Hb). However,
under normal physiological conditions, the encapsulation of Hb inside red blood cells
(RBCs) significantly retards NO scavenging, permitting NO to reach the smooth muscle. The
rate-limiting factors (diffusion of NO to the RBC surface, through the RBC membrane or
inside of the RBC) responsible for this retardation have been the subject of much debate …
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